An Unexpectedly Complex Architecture for Skin Pigmentation in Africans

Posted in Africa, Articles, Health/Medicine/Genetics, Media Archive on 2017-12-03 03:40Z by Steven

An Unexpectedly Complex Architecture for Skin Pigmentation in Africans

Cell
Volume 171, Issue 6, 2017-11-30
pages 1340–1353.e14
DOI: 10.1016/j.cell.2017.11.015

Alicia R. Martin, Meng Lin, Julie M. Granka, Justin W. Myrick, Xiaomin Liu, Alexandra Sockell, Elizabeth G. Atkinson, Cedric J. Werely, Marlo Möller, Manjinder S. Sandhu, David M. Kingsley, Eileen G. Hoal, Xiao Liu, Mark J. Daly, Marcus W. Feldman, Christopher R. Gignoux, Carlos D. Bustamante, Brenna M. Henn

Highlights

  • Skin pigmentation in Africans is far more polygenic than light skin in Eurasians
  • Southern African KhoeSan populations have lighter skin compared to equatorial Africans
  • Highly heritable KhoeSan skin color variation is poorly explained by known genes
  • The study of African skin color identifies novel and canonical pigmentation genes

Approximately 15 genes have been directly associated with skin pigmentation variation in humans, leading to its characterization as a relatively simple trait. However, by assembling a global survey of quantitative skin pigmentation phenotypes, we demonstrate that pigmentation is more complex than previously assumed, with genetic architecture varying by latitude. We investigate polygenicity in the KhoeSan populations indigenous to southern Africa who have considerably lighter skin than equatorial Africans. We demonstrate that skin pigmentation is highly heritable, but known pigmentation loci explain only a small fraction of the variance. Rather, baseline skin pigmentation is a complex, polygenic trait in the KhoeSan. Despite this, we identify canonical and non-canonical skin pigmentation loci, including near SLC24A5, TYRP1, SMARCA2/VLDLR, and SNX13, using a genome-wide association approach complemented by targeted resequencing. By considering diverse, under-studied African populations, we show how the architecture of skin pigmentation can vary across humans subject to different local evolutionary pressures.

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Doing Race: 21 Essays for the 21st Century

Posted in Anthologies, Anthropology, Books, Census/Demographics, Communications/Media Studies, History, Law, Media Archive on 2010-06-24 18:55Z by Steven

Doing Race: 21 Essays for the 21st Century

W. W. Norton and Company
April 2010
590 pages
6.2 × 9.3 in
Paperback ISBN: 978-0-393-93070-2

Hazel Rose Markus (Editor)
Stanford University

Paula M. L. Moya (Editor)
Stanford University

A collection of new essays, written by a team of interdisciplinary authors, that gives a comprehensive introduction to race and ethnicity.

In Doing Race, scholars from across the disciplines have written original essays on race and ethnicity aimed at an undergraduate audience. The book provides a practical response to the view, common in American debates, that race and ethnicity no longer matter, or that race and ethnicity should not be taken into account when deciding how to structure society and formulate public policy. It also answers the question of why race and ethnicity play such a large role in fueling violence around the globe.

Doing Race shows that race and ethnicity matter because they are important resources in answering the fundamental, even universal “Who am I?” and “Who are we?” questions. It demonstrates how understanding how identities are shaped by race and ethnicity is central to understanding individual and collective behavior in the United States and throughout the world.

Drawing on the latest science and scholarship, these original essays provide undergraduates with an effective framework for understanding the persistence of racial inequalities and problems in the 21st century.

Table of Contents:

Introduction: Doing Race

Hazel Rose Markus

      and

Paula M. L. Moya

Part I: Inventing Race and Ethnicity

  • Defining Race and Ethnicity: The Constitution, the Court, and the Census, C. Matthew Snipp, Sociology
  • Models of American Ethnic Relations: Hierarchy, Assimilation, and Pluralism, George Fredrickson, History
  • The Biology of Ancestry: DNA, Genomic Variation, and Race, Marcus W. Feldman, Biology
  • Which Differences Make a Difference? Race, Health, and DNA, Barbara Koenig, Medical Anthropology

Part II: Racing Difference

  • The Jew as the Original ‘Other’: Difference, Antisemitism, and Race, Aron Rodrigue, History
  • Knowing the ‘Other’: Arabs, Islam, and the West, Joel Beinin, History
  • Eternally Foreign: Asian Americans, History, and Race, Gordon H. Chang, History
  • A Thoroughly Modern Concept: Ethnic Cleansing, Genocide, and the State, Norman M. Naimark, History

Part III: Institutionalizing Difference

  • Race in the News: Stereotypes, Political Campaigns, and Market-Based Journalism, Shanto Iyengar, Communication and Political Science
  • Going Back to Compton: Real Estate, Racial Politics, and Black-Brown Relations, Albert M. Camarillo, History
  • Structured for Failure: Race, Resources, and Student Achievement, Linda Darling-Hammond, Education
  • Racialized Mass Incarceration: Poverty, Prejudice, and Punishment, Lawrence D. Bobo and Victor Thompson, Sociology

Part IV: Racing Identity

  • Who Am I? Race, Ethnicity, and Identity, Hazel Rose Markus, Psychology
  • In the Air Between Us: Stereotypes, Identity, and Achievement, Claude M. Steele, Psychology
  • Ways of Being White: Privilege, Stigma, and Transcendence, Monica McDermott, Sociology
  • Blacks as Criminal, Blacks as Apes: Race, Representation, and Social Justice, Jennifer L. Eberhardt, Psychology
  • We’re Honoring You Dude: Myths, Mascots, and American Indians, Stephanie Fryberg and Alisha Watts, Psychology

Part V: Re-presenting Reality

  • Another Way to Be: Women of Color, Literature, and Myth, Paula M. L. Moya, English
  • Hiphop and Race: Blackness, Language, and Creativity, Marcyliena Morgan and Dawn-Elissa Fischer, African and African American Studies and Africana Studies
  • The ‘Ethno-Ambiguo Hostility Syndrome’: Mixed-Race, Identity, and Popular Culture, Michele Elam, English
  • ‘We wear the mask’: Performance, Social Dramas, and Race, Harry Elam, Drama
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