Mixed Race Studies

Genetic ancestry data improve diagnosis in asthma and lung disease

University of California, San Fransisco
News Release
2010-07-07

Kristen Bole

Released Jointly by UCSF and Northwestern University Feinberg School of Medicine, Henry Ford Hospital, and National Jewish Health

Americans with lung disease may face a far greater level of lung damage than either they or their doctor suspect, depending on their individual genetic heritage, according to a study released July 7. The research implications range from diagnosing the severity of asthma to disability decisions or eligibility for lung transplants, researchers say.

In the largest study of its kind to date, spanning a dozen research centers and pooling data on more than 3,000 patients, a team of researchers led by UCSF and Northwestern University found that patients’ precise genetic background told far more about their potential lung function – and therefore any damage that has occurred – than the self-identified racial profile commonly used in such tests.

The results point to a more precise method of assessing patients’ lung function, as well as the potential impact of using precise genetic benchmarks for assessing health overall, researchers say. Findings will appear in the July 22 print edition of the “New England Journal of Medicine” and online on July 7 at nejm.org.

…Standard race categories, however, don’t capture the extent of our ancestral diversity, according to the paper’s senior author, Esteban G. Burchard, MD, MPH, who is director of the UCSF Center for Genes, Environment and Health, and a member of the Department of Bioengineering and Therapeutic Sciences, a joint department between the UCSF schools of Medicine and Pharmacy.

“People throughout the world have a richer genetic heritage than can be captured by our current definitions of race,” Burchard said, noting that almost every continent has large populations that are known to be genetically mixed. “When we force patients into an individual box, such as ‘African-American’ or ‘Caucasian’, we’re missing a lot of genetic information.”

While this study focused on patients who define themselves as African-Americans, the participants’ actual genetic ancestry ranged broadly and included Caucasian and African heritage…

To read the entire article, click here.

Claiming the (n)either/(n)or of ‘third space’: (re)presenting hybrid identity and the embodiment of mixed race

Journal of Intercultural Studies
Volume 25, Issue 1 (April 2004)
pages 75 – 85
DOI: 10.1080/07256860410001687036

Torika Bolatagici, Associate Lecturer
School of Communication & Creative Arts
Deakin University, Melbourne, Austrailia

As a multiracial artist, I am interested in how people of mixed race have been represented in popular culture and how mixed race image-makers can redress popular representation and facilitate a movement beyond the dichotomy, which seeks to reduce us to the sum of our parts. In the footsteps of Evelyn Alsultany I advocate the creation of a new cartography—a space that is inclusive and beyond existing notions of race. To this end I embarked on a project of exploration of the representation of multiracial identity, drawing from Homi K. Bhabha’s notion of Third Space.

Read or purchase the article here.

The more things change, the more they stay the same

Thinking Twice: RACE
The Stanford Review
2009-01-29

C. Matthew Snipp, Professor of Sociology and Director of the Center for Comparative Studies in Race and Ethnicity
Stanford University

Last week, we inaugurated our first African American president, and coincidentally our first mixed race president, and our first Hawaiian president. The first of these three events captured the public imagination while the other two have passed with barely a comment, and for good reason. Few Americans know the sordid history behind the acquisition of Hawaii. Fewer still have parsed what it means to be multiracial in America. But most Americans are well aware of the travails of African Americans, from slavery to Jim Crow to the Civil Rights movement.

Trolling the news outlets since the November elections yields two seemingly dissonant messages. One is that Obama’s election signals a new era in race relations—that we are living in a “post-civil rights” era, an era of “color blindness.” The New York Times recently published a glowing story about an interracial couple who suddenly have found it less awkward to have to conversations with their friends about racial differences. In contrast, others are quick to point out that racism is alive and well in America, and that Obama’s election will mean little for changing the racial partition that has existed in this country since its inception….

Read the entire article here.

Why Obama is Black Again

Thinking Twice: RACE
The Stanford Review
2009-01-29

Michele Elam, Martin Luther King, Jr. Centennial Professor of English and Olivier Nomellini Family University Fellow in Undergraduate Education
Stanford University

Barack Obama’s inauguration was for so many an awe-inspiring, historic and transnational event: It was full of grand pageantry and a good-humored pomp and circumstance that made D.C. the place to be. People were called together in many ways, and one of the more important ways they were asked to unite was over the contentious matter of race.

But it is worthwhile noting that this unlikely racial consensus was achieved through a strategic kind of absenting: Gone from the inaugural coverage were all the hand-wringing equivocations preceding the Democratic nomination about whether Obama’s person and politics went “beyond race” (and if that was a good thing or not), whether he even met the minimum standards for blackness (it was never clear who got to wield this racial measuring stick), or whether he was capitalizing on what novelist Danzy Senna calls the “mulatto millennium” of mixed-race celebrities…

Read the entire article here.

Questions for Maya Soetoro-Ng: All in the Family

The New York Times
2008-01-20

Deborah Solomon

Q: Let’s talk about the Democratic presidential caucuses taking place on Feb. 19, in Hawaii, where Barack Obama was born. Will you be campaigning for your brother?
Yes, of course. I have taken time off from my various teaching jobs in Honolulu and just got back from two months of campaigning. I have a bumper sticker on my car that says: “1-20-09. End of an Error.”…

Do you think of your brother as black?
Yes, because that is how he has named himself. Each of us has a right to name ourselves as we will.

Do you think of yourself as white?
No. I’m half white, half Asian. I think of myself as hybrid. People usually think I’m Latina when they meet me. That’s what made me learn Spanish.

That sort of culturally mixed identity was seen as an anomaly when you were growing up.
Of course, there was a time when that felt like unsteady terrain, and it made me feel vulnerable…

Read the entire interview here.

Obama’s Mixology

The Root
2008-10-30

Michele Elam, Martin Luther King, Jr. Centennial Professor of English and Olivier Nomellini Family University Fellow in Undergraduate Education
Stanford University

Give Obama credit for not trying to use his biracial background as an appeal to white working-class voters.

Mix’ology: noun. The art and science of mixings

In these final days of this presidential campaign, John McCain and his supporters have been trying desperately to raise doubts about Barack Obama’s identity. They have called him a terrorist sympathizer, a socialist, an unrepentant liberal. For weeks, their tagline has been “Who is Barack Obama?” The McCain campaign hopes that the question will resonate with the part of the electorate that Obama had putatively most alienated: the white, working class.

For different reasons, this same identity question has also had some traction with people of color, many of whom worry that Obama will usher in what Danzy Senna calls the “mulatto millennium,” especially if it implies that, as some of Obama’s supporters chanted earlier this year, “race doesn’t matter.”…

…But Obama has rejected post-racialism, certainly to the extent it meant identifying as “mixed” rather than “black.” His position was evident as early as 2005, when he told representatives from the MAVIN Foundation, one of the nation’s largest mixed-race advocacy organizations, who had clearly hoped he would be both an icon and legislative whip on their behalf: “I am always cautious about…persons of mixed race focusing so narrowly on their own unique experiences that they are detached from larger struggles, and I think it’s important to try to avoid that sense of exclusivity, and feeling that you’re special in some way.”

As his Indonesian-Caucasian sister, Maya Soetoro-Ng, noted, Obama identifies as black not because he is conscripted by the one-drop rule, but because he actively chooses it. He belongs to the black community not only because, historically, mixed people have always belonged, and because black has never been pure; he belongs also, his sister suggests, because of personal commitment and responsibility. The issue may appear moot since race is part choice, part social ascription, and Obama could not simply opt out of the race even if he woke up some morning and chose to. But it remains important that he does not bill himself as “mixed” or “other” even when it might appear politically convenient or grant him cultural glam…

Read the entire article here.

Barack Obama and the Charm of the Stranger

The Zeleza Post
2009-01-25

Francis Njubi Nesbitt, Associate Professor of Africana Studies
San Diego State University

What is source of Barack Obama’s charm? Why was he able to win over whites, blacks and Latinos in a country that is famously partisan? Arguably, there are politicians who are equally gifted but there is seems to be a special aura about Obama.

Commentators have noted how he seems to absorb difference. They project their hopes and dreams on him. He has an aura of objectivity. People trust him. These are all qualities of a particular type of personality referred to in the literature as “the stranger,” “the outsider,” or “the marginal man.”

In an influential essay titled “The Stranger,” the Jewish scholar Georg Simmel argued that the stranger is by nature “no owner of the soil” and thus is able to absorb difference and project an aura of objectivity. Some may be comfortable confessing to the stranger actions and thoughts that hey keep from insiders. According to Simmel: “The stranger may develop charm and significance as long as he is considered a stranger in the eyes of the other, he is not an owner of the soil.”

Both Georg Simmel in “The Stranger,” and his student, Robert E. Park in “Migration and the Marginal Man,” argue that this personality type is often found among people of mixed race or excluded minorities who are caught between two cultures. They are forced to learn both their native ways and the ways of the majority population. W. E. B. Du Bois, Park’s contemporary and also a biracial man, put it eloquently in his famous lament about “double consciousness” that he wished to “merge my double self into a new and truer self.”

The problem, of course, is that it was not possible to resolve this double consciousness because of the one-drop rule that defined biracial individuals as black. The Jewish intellectual in Germany faced the same dilemma. He is caught between cultures, the rural and the urban, the Jewish and the German. One could not be both Jewish and German at the same time just like one could not be black and white at the same time…

Read the entire article here.

DNA tests probe the genomic ancestry of Brazilians

Brazilian Journal of Medical and Biological Research
Volume 42, Number 10 (October 2009)
pages 870-876
DOI: 10.1590/S0100-879X2009005000026

S .D. J. Pena
GENE, Núcleo de Genética Médica, Belo Horizonte, MG, Brasil
Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil

L. Bastos-Rodrigues
Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil

J. R. Pimenta
GENE, Núcleo de Genética Médica, Belo Horizonte, MG, Brasil

S. P. Bydlowski
Laboratório de Genética e Hematologia Molecular (LIM-31), Faculdade de Medicina, Universidade de São Paulo, Hospital das Clínicas, São Paulo, SP, Brasil

We review studies from our laboratories using different molecular tools to characterize the ancestry of Brazilians in reference to their Amerindian, European and African roots. Initially we used uniparental DNA markers to investigate the contribution of distinct Y chromosome and mitochondrial DNA lineages to present-day populations. High levels of genetic admixture and strong directional mating between European males and Amerindian and African females were unraveled. We next analyzed different types of biparental autosomal polymorphisms. Especially useful was a set of 40 insertion-deletion polymorphisms (indels) that when studied worldwide proved exquisitely sensitive in discriminating between Amerindians, Europeans and Sub-Saharan Africans. When applied to the study of Brazilians these markers confirmed extensive genomic admixture, but also demonstrated a strong imprint of the massive European immigration wave in the 19th and 20th centuries. The high individual ancestral variability observed suggests that each Brazilian has a singular proportion of Amerindian, European and African ancestries in his mosaic genome. In Brazil, one cannot predict the color of persons from their genomic ancestry nor the opposite. Brazilians should be assessed on a personal basis, as 190 million human beings, and not as members of color groups.

Introduction

Brazilians are one of the most heterogeneous populations in the world, the result of five centuries of interethnic crosses between peoples from three continents: Amerindians, Europeans and Africans. Little is known about the number of indigenous people living in the area of what is now Brazil when the Portuguese arrived in 1500 (1), although a figure often cited is that of 2.5 million individuals. The Portuguese-Amerindian admixture started soon after the arrival of the first colonizers and later became commonplace, being even encouraged after 1755 as a strategy for population growth and colonial occupation of the country….

From the middle of the 16th century, Africans were brought to Brazil to work on sugarcane farms and, later, in the gold and diamond mines and on coffee plantations. Historical records suggest that between circa 1550 and 1850 (when the slave trade was abolished), around four million Africans arrived in Brazil (2)…

Uniparental genetic markers in Brazilians

…To learn about the maternal counterpart, we analyzed mtDNA, which revealed a different reality. Considering Brazil as a whole, 33, 39, and 28% of matrilineages were of Amerindian, European and African origin, respectively (9,12). As expected, the frequency of different regions reflected their genealogical histories: most matrilineal lineages in the Amazon region were of Amerindian origin, while African ancestrality was preponderant in the Northeast (44%) and European haplogroups were prevalent in the South (66%). These data have since been amply confirmed by numerous other studies. For instance, we recently analyzed the mtDNA haplogroup structure of 242 self-identified white individuals from São Paulo and ascertained 24% Amerindian, 22% African and 54% European matrilineal proportions (Dornelas HG, Bydlowski SP, Pena SDJ, unpublished data).

Next, for further confirmation, we studied mtDNA lineages in 120 black individuals from the city of São Paulo. The results, as expected, showed a mirror image of those previously found in white Brazilians: on the one hand, 85% of the lineages originated in Sub-Saharan Africa, 12% were from Amerindians and only 3% were from Europe; on the other, only 48% of the Y chromosome lineages originated from Sub-Saharan Africa (the vast majority belonging to haplogroups E3a7 and E3a*). Studies on black individuals from the cities of Rio de Janeiro and Porto Alegre produced very similar results.

Taken together, these numbers disclose a picture of very strong directional mating between European males and Amerindian and African females, which agrees perfectly with the known history of the peopling of Brazil since 1500. These studies also reveal that the genomes of most Brazilians are mosaic, having mtDNA and NRY of different phylogeographical origins.

Biparental genetic markers and ancestry in Brazilians

In Brazil, notwithstanding relatively large levels of genetic admixture and a myth of “racial democracy”, there exists widespread social prejudice that seems to be particularly connected to the physical appearance of an individual. Color (in Portuguese, cor) denotes the Brazilian equivalent of the English term race (raça) and is based on a complex phenotypic evaluation that takes into account, besides skin pigmentation, also hair type, nose shape and lip shape. The reason why the word color is preferred to race in Brazil is probably because it captures the continuous aspects of phenotypes. In contrast with the situation in the United States, there appears to be no racial descent rule operational in Brazil and it is possible for two siblings differing in color to belong to completely diverse racial categories.

Based on the criteria of self-classification of the 2000 census of the Instituto Brasileiro de Geografia e Estatística (IBGE), the Brazilian population was then composed of 53.4% Whites, 6.1% Blacks and 38.9% Brown (“pardos” in Portuguese). How do these numbers correlate with genomic ancestry?..

Read the entire article here.

Reading between the (Blood) Lines

Southern California Law Review
Volume 83, Number 3 (2010)
pages 473-494

Rose Cuison Villazor, Professor of Law
Hofstra University School of Law

Legal scholars and historians have depicted the rule of hypodescent—that “one drop” of African blood categorized one as Black—as one of the powerful ways that law and society deployed to construct racial identities and deny equal citizenship. Ariela J. Gross’s new book, “What Blood Won’t Tell: A History of Race on Trial in America,” boldly complicates the dominant narrative about hypodescent rules in legal scholarship. On the one hand, “What Blood Won’t Tell” argues that the legal and social construction of race was far more complex, flexible and subject to manipulation than the scholarship regarding the rules about blood distinctions has suggested. On the other hand, “What Blood Won’t Tell” highlights circumstances, both historically and in recent memory, of the ways in which blood distinctions played crucial roles in shaping the identity of people of color, including indigenous peoples. Importantly, “What Blood Won’t Tell” also examines how blood quantum rules relate to contemporary efforts to reassert indigenous peoples’ sovereignty and claims to lands.

This Review highlights the important contributions of “What Blood Won’t Tell” to our understanding of the racial experience of indigenous peoples and the contemporary methods used to remedy the present-day effects of indigenous peoples’ colonial experience. “What Blood Won’t Tell” advances a more robust account of the racialization of people of color through rules about blood differences in at least three ways. First, it places the colonial experience of indigenous peoples within the larger historical contexts of racial subordination and efforts to promote White domination and privilege. Second, it underscores the federal government’s ongoing responsibility to counteract the long-standing effects of its past misdeeds by addressing indigenous peoples’ unresolved claims to lands that have been stolen from them. Third, it allows us to take a careful look at the relationship between blood quantum rules and the right of indigenous peoples to exercise self-determination. Taken together, these three perspectives reveal the immense challenges inherent to remedying the long-term effects of the racialization and colonization of indigenous peoples.

Read the entire article here.

Professor Marsha Daria to be Featured Guest on Mixed Chicks Chat

Mixed Chicks Chat (The only live weekly show about being racially and culturally mixed. Also, founders of the Mixed Roots Film & Literary Festival) Hosted by Fanshen Cox and Heidi W. Durrow
Website: TalkShoe™ (Keywords: Mixed Chicks)
Episode: #160 – Professor Marsha D. Daria
When: Wednesday, 2010-06-30, 21:00Z (17:00 EDT, 14:00 PDT)

Marsha D. Daria, Associate Professor of Education (dariam@wcsu.edu)
Western Connecticut State University

Marsha D. Daria, Ph. D., Associate Professor of Education at Western Connecticut State University, is a former principal and classroom teacher. Her research interests are in multicultural education and health issues. She is currently working on a documentary about multiracial children.